Exonic polymorphism (rs315952, Ser133Ser) of interleukin 1 receptor antagonist (IL1RN) is related to overweigh/obese with hypertension

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Exonic polymorphism (rs315952, Ser133Ser) of interleukin 1 receptor antagonist (IL1RN) is related to overweigh/obese with hypertension

Recent studies demonstrated that interleukin 1 receptor antagonist (IL-1RN) plays an important role in metabolic effects. To investigate whether IL1RN polymorphisms are associated with obesity, two single nucleotide polymorphisms (SNPs) of the IL1RN gene [rs4251961 (-828, T> C) and rs315952 (Ser133Ser)] were analyzed in 122 overweigh/obese and 123 control subjects. Overweigh/obese subjects were...

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association between interleukin-1 receptor antagonist (il1rn) variable number of tandem repeats (vntr) polymorphism and pulmonary tuberculosis.

macrophages and t-lymphocytes are involved in immune response to mycobacterium tuberculosis. macrophage produces interleukin (il)-1 as an inflammatory mediator. il-1 receptor antagonist (il1-ra) is a natural antagonist of il-1 receptors. in this study we aimed to examine the possible association between the variable number of tandem repeats (vntr) of the il-1 receptor antagonist (il1rn) gene an...

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Interleukin-1 receptor antagonist (IL1RN) is associated with suppression of early carcinogenic events in human oral malignancies.

Inflammatory abnormalities have been implicated in the pathogenesis of various human diseases, including cancer. Interleukin-1 receptor antagonist (IL1RN) is a potent anti-inflammatory molecule that modulates the biological activity of the proinflammatory cytokine, interleukin-1. The aim of this study was to examine the expression of IL1RN in oral squamous cell carcinomas (OSCCs), and to determ...

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Influence of interleukin-1 receptor antagonist gene polymorphism on disease.

Interleukin-1 receptor antagonist (IL-1RA) is a naturally occurring competitive inhibitor of interleukin-1 (IL-1)-induced proinflammatory activity. The IL-1RA gene is polymorphic, resulting in quantitative differences in both IL-1RA and IL-1beta production. Persons homozygous for allele 2 of the IL-1RA gene (IL1RN*2) have a more prolonged and more severe proinflammatory immune response than per...

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Interleukin-1 receptor antagonist gene VNTR polymorphism is associated with coronary artery disease.

BACKGROUND Coronary Artery Disease (CAD) is the atherosclerosis of coronary arteries that carry blood to the heart muscle. Atherosclerosis is an inflammatory disease. Cytokine gene variations such as those associated with the IL1 family are involved in the pathogenesis of atherosclerosis. OBJECTIVE The purpose of this study was to determine the relationship between IL1 family polymorphisms (I...

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ژورنال

عنوان ژورنال: Journal of Exercise Rehabilitation

سال: 2014

ISSN: 2288-176X,2288-1778

DOI: 10.12965/jer.140155